Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study
المؤلفون المشاركون
Horton, Terzah M.
Hutchison, Robert E.
Narendra, Sonia
López-Terrada, Dolores
Wu, Meng-Fen
Sheehan, Andrea M.
Liu, Hao
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Constitutively active nuclear factor-κB (NF-κB) is integral to the survival of Hodgkin/Reed-Sternberg cells (H/RS) in Hodgkin lymphoma (HL).
To investigate NF-κB pathway proteins in pediatric HL, we utilized a tissue microarray compiled from 102 children enrolled in the Children's Oncology Group intermediate-risk clinical trial AHOD0031 (56 male, 78 Caucasian, median age 15 years (range 1–20 years), 85 nodular sclerosing subtype, 23 Epstein-Barr virus (EBV) positive, and 24 refractory/relapsed disease).
We examined the intensity, localization, and pathway correlations of NF-κB pathway proteins (Rel-A/p65, Rel-B, c-Rel, NF-κB1, NF-κB2, IκB-α, IKK-α, IKK-β, IKK-γ/NEMO, NIK, and A20), as well as their associations with EBV status and clinical outcome.
NF-κB pathway proteins were overexpressed in pediatric HL patients compared to controls.
Patients with EBV− tumors, or with rapid early therapy response, had tightly coordinated regulation of NF-κB pathway proteins, whereas patients with EBV+ tumors, or slow early therapy response, had little coordinated NF-κB pathway regulation.
High NIK expression was associated with a slow response to therapy and decreased EFS.
Elevated Rel-B, NIK, and the NF-κB inhibitor A20 were associated with decreased EFS in multivariate analysis.
These studies suggest a pivotal role for the NF-κB pathway in therapy response and patient survival in Hodgkin lymphoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Horton, Terzah M.& Sheehan, Andrea M.& López-Terrada, Dolores& Hutchison, Robert E.& Narendra, Sonia& Wu, Meng-Fen…[et al.]. 2012. Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study. Lymphoma،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-464248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Horton, Terzah M.…[et al.]. Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study. Lymphoma No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-464248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Horton, Terzah M.& Sheehan, Andrea M.& López-Terrada, Dolores& Hutchison, Robert E.& Narendra, Sonia& Wu, Meng-Fen…[et al.]. Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study. Lymphoma. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-464248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر