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Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study
المؤلفون المشاركون
Horton, Terzah M.
Hutchison, Robert E.
Narendra, Sonia
López-Terrada, Dolores
Wu, Meng-Fen
Sheehan, Andrea M.
Liu, Hao
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Constitutively active nuclear factor-κB (NF-κB) is integral to the survival of Hodgkin/Reed-Sternberg cells (H/RS) in Hodgkin lymphoma (HL).
To investigate NF-κB pathway proteins in pediatric HL, we utilized a tissue microarray compiled from 102 children enrolled in the Children's Oncology Group intermediate-risk clinical trial AHOD0031 (56 male, 78 Caucasian, median age 15 years (range 1–20 years), 85 nodular sclerosing subtype, 23 Epstein-Barr virus (EBV) positive, and 24 refractory/relapsed disease).
We examined the intensity, localization, and pathway correlations of NF-κB pathway proteins (Rel-A/p65, Rel-B, c-Rel, NF-κB1, NF-κB2, IκB-α, IKK-α, IKK-β, IKK-γ/NEMO, NIK, and A20), as well as their associations with EBV status and clinical outcome.
NF-κB pathway proteins were overexpressed in pediatric HL patients compared to controls.
Patients with EBV− tumors, or with rapid early therapy response, had tightly coordinated regulation of NF-κB pathway proteins, whereas patients with EBV+ tumors, or slow early therapy response, had little coordinated NF-κB pathway regulation.
High NIK expression was associated with a slow response to therapy and decreased EFS.
Elevated Rel-B, NIK, and the NF-κB inhibitor A20 were associated with decreased EFS in multivariate analysis.
These studies suggest a pivotal role for the NF-κB pathway in therapy response and patient survival in Hodgkin lymphoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Horton, Terzah M.& Sheehan, Andrea M.& López-Terrada, Dolores& Hutchison, Robert E.& Narendra, Sonia& Wu, Meng-Fen…[et al.]. 2012. Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study. Lymphoma،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-464248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Horton, Terzah M.…[et al.]. Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study. Lymphoma No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-464248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Horton, Terzah M.& Sheehan, Andrea M.& López-Terrada, Dolores& Hutchison, Robert E.& Narendra, Sonia& Wu, Meng-Fen…[et al.]. Analysis of NF-κB Pathway Proteins in Pediatric Hodgkin Lymphoma : Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study. Lymphoma. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-464248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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