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Metabolic Profiling of Patients Undergoing Elective Aortic Aneurysm Repair Surgery : Correlation with Anaerobic Threshold
المؤلفون المشاركون
Howell, Simon J.
Fisher, Julie
Howard, Susan
Homer-Vanniasinkam, Shervanthi
McRae, Cassey
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The anaerobic threshold (AT) measured by the cardiopulmonary exercise (CPX) test is becoming an established means of identifying patients at high risk of developing cardiac complications perioperatively.
The aim of the present study was to investigate the relationship between AT and the plasma metabolic profile of patients undergoing aortic aneurysm repair surgery to see if an alternative or adjunct to the CPX test could be devised.
Plasma was obtained from 15 male patients classified (through preoperative CPX tests) as having high (≥11.0 mL kg−1 min−1) or low (<11.0 mL kg−1 min−1) AT before and 1, 2, 24, 48, and 72 hours after elective open aortic aneurysm surgery.
Samples were analysed using 1H-NMR spectroscopy coupled with multivariate statistical analysis.
Principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA) distinguished between low- and high-AT patients postoperatively, with high AT patients being more tightly clustered.
High AT patients had higher plasma lipid and lower 3-hydroxybutyrate and acetoacetate levels than low AT patients post-operatively.
Similar differences were identified preoperatively.
1H-NMR metabolic profiling of plasma has identified molecules whose concentration correlates with AT scores.
These may prove a useful biomarker in conjunction with AT in predicting response to major surgical procedures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McRae, Cassey& Howard, Susan& Homer-Vanniasinkam, Shervanthi& Howell, Simon J.& Fisher, Julie. 2012. Metabolic Profiling of Patients Undergoing Elective Aortic Aneurysm Repair Surgery : Correlation with Anaerobic Threshold. ISRN Vascular Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-464267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McRae, Cassey…[et al.]. Metabolic Profiling of Patients Undergoing Elective Aortic Aneurysm Repair Surgery : Correlation with Anaerobic Threshold. ISRN Vascular Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-464267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McRae, Cassey& Howard, Susan& Homer-Vanniasinkam, Shervanthi& Howell, Simon J.& Fisher, Julie. Metabolic Profiling of Patients Undergoing Elective Aortic Aneurysm Repair Surgery : Correlation with Anaerobic Threshold. ISRN Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-464267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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