Requirements for Human Respiratory Syncytial Virus Glycoproteins in Assembly and Egress from Infected Cells
المؤلفون المشاركون
Batonick, Melissa
Wertz, Gail W.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Human respiratory syncytial virus (HRSV) is an enveloped RNA virus that assembles and buds from the plasma membrane of infected cells.
The ribonucleoprotein complex (RNP) must associate with the viral matrix protein and glycoproteins to form newly infectious particles prior to budding.
The viral proteins involved in HRSV assembly and egress are mostly unexplored.
We investigated whether the glycoproteins of HRSV were involved in the late stages of viral replication by utilizing recombinant viruses where each individual glycoprotein gene was deleted and replaced with a reporter gene to maintain wild-type levels of gene expression.
These engineered viruses allowed us to study the roles of the glycoproteins in assembly and budding in the context of infectious virus.
Microscopy data showed that the F glycoprotein was involved in the localization of the glycoproteins with the other viral proteins at the plasma membrane.
Biochemical analyses showed that deletion of the F and G proteins affected incorporation of the other viral proteins into budded virions.
However, efficient viral release was unaffected by the deletion of any of the glycoproteins individually or in concert.
These studies attribute a novel role to the F and G proteins in viral protein localization and assembly.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Batonick, Melissa& Wertz, Gail W.. 2011. Requirements for Human Respiratory Syncytial Virus Glycoproteins in Assembly and Egress from Infected Cells. Advances in Virology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-464397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Batonick, Melissa& Wertz, Gail W.. Requirements for Human Respiratory Syncytial Virus Glycoproteins in Assembly and Egress from Infected Cells. Advances in Virology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-464397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Batonick, Melissa& Wertz, Gail W.. Requirements for Human Respiratory Syncytial Virus Glycoproteins in Assembly and Egress from Infected Cells. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-464397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر