Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis
المؤلفون المشاركون
Rui, Ke
Wang, Shengjun
Tian, Jie
Tong, Jia
Wu, Wei
Zhang, Yue
Lu, Liwei
Tang, Xinyi
Xu, Huaxi
Tian, Xinyu
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis).
In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients.
Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients.
Secondly, we found that there was a positive correlation between the percentages of Th17 cells and serum level of CK in DM patients.
And the serum concentrations of IL-6, IL-1β, TGF-β, and IL-23, the important cytokines of Th17 differentiation, were increased in DM patients.
It was predicted that Krüppel-like factor 4 (KLF4) is one of the multiple targets of miR-206.
We detected the expression of miR-206 in DM patients, and it was decreased in the serum and PBMCs of DM patients.
The augmented expression of KLF is accompanied by the attenuated expression of miR-206.
Furthermore, a negative correlation between the percentages of Th17 cells and the expression of miR-206 in DM patients has been found.
Taken together, these findings suggest the attenuated expression of miR-206, and the augmented frequency of Th17 cells in DM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Xinyi& Tian, Xinyu& Zhang, Yue& Wu, Wei& Tian, Jie& Rui, Ke…[et al.]. 2013. Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Xinyi…[et al.]. Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-464476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Xinyi& Tian, Xinyu& Zhang, Yue& Wu, Wei& Tian, Jie& Rui, Ke…[et al.]. Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر