An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles
المؤلفون المشاركون
Zhao, Yang
Guo, Li
Zhang, Hui
Chen, Feng
Yang, Sheng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Increasing amounts of evidence indicate that noncoding RNAs (ncRNAs) have important roles in various biological processes.
Here, miRNA, lncRNA, and mRNA expression profiles were analyzed in human HepG2 and L02 cells using high-throughput technologies.
An integrative method was developed to identify possible functional relationships between different RNA molecules.
The dominant deregulated miRNAs were prone to be downregulated in tumor cells, and the most abnormal mRNAs and lncRNAs were always upregulated.
However, the genome-wide analysis of differentially expressed RNA species did not show significant bias between up- and downregulated populations.
miRNA-mRNA interaction was performed based on their regulatory relationships, and miRNA-lncRNA and mRNA-lncRNA interactions were thoroughly surveyed and identified based on their locational distributions and sequence correlations.
Aberrantly expressed miRNAs were further analyzed based on their multiple isomiRs.
IsomiR repertoires and expression patterns were varied across miRNA loci.
Several specific miRNA loci showed differences between tumor and normal cells, especially with respect to abnormally expressed miRNA species.
These findings suggest that isomiR repertoires and expression patterns might contribute to tumorigenesis through different biological roles.
Systematic and integrative analysis of different RNA molecules with potential cross-talk may make great contributions to the unveiling of the complex mechanisms underlying tumorigenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Li& Zhao, Yang& Yang, Sheng& Zhang, Hui& Chen, Feng. 2014. An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-464483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Li…[et al.]. An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-464483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Li& Zhao, Yang& Yang, Sheng& Zhang, Hui& Chen, Feng. An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-464483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر