Ductal Carcinoma In Situ : Recent Advances and Future Prospects

المؤلفون المشاركون

Mokbel, Kefah
Lambert, Kelly
Patani, Neill

المصدر

International Journal of Surgical Oncology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-17

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Introduction.

This article reviews current management strategies for DCIS in the context of recent randomised trials, including the role of sentinel lymph node biopsy (SLNB), adjuvant radiotherapy (RT) and endocrine treatment.

Methods.

Literature review facilitated by Medline, PubMed, Embase and Cochrane databases.

Results.

DCIS should be managed in the context of a multidisciplinary team.

Local control depends upon clear surgical margins (at least 2 mm is generally acceptable).

SLNB is not routine, but can be considered in patients undergoing mastectomy (Mx) with risk factors for occult invasion.

RT following BCS significantly reduces local recurrence (LR), particularly in those at high-risk.

There remains a lack of level-1 evidence supporting omission of adjuvant RT in selected low-risk cases.

Large, multi-centric or recurrent lesions should be treated by Mx and immediate reconstruction should be discussed.

Adjuvant hormonal treatment may reduce the risk of LR in selected cases with hormone sensitive disease.

Conclusion.

Further research is required to determine the role of new RT regimes and endocrine therapies.

Biological profiling and molecular analysis represent an opportunity to improve our understanding of tumour biology in DCIS to rationalise treatment.

Reliable identification of low-risk lesions could allow treatment to be less radical.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lambert, Kelly& Patani, Neill& Mokbel, Kefah. 2012. Ductal Carcinoma In Situ : Recent Advances and Future Prospects. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464641

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lambert, Kelly…[et al.]. Ductal Carcinoma In Situ : Recent Advances and Future Prospects. International Journal of Surgical Oncology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-464641

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lambert, Kelly& Patani, Neill& Mokbel, Kefah. Ductal Carcinoma In Situ : Recent Advances and Future Prospects. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464641

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-464641