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Adverse Event Burden, Resource Use, and Costs Associated with Immunosuppressant Medications for the Treatment of Systemic Lupus Erythematosus : A Systematic Literature Review
المؤلفون المشاركون
Dennis, G.
Oglesby, A.
Weinstein, A.
Shaul, A. J.
Pokora, T.
Narayanan, S.
Paramore, C.
Cragin, L.
المصدر
International Journal of Rheumatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This paper assessed the burden of adverse events (AEs) associated with azathioprine (AZA), cyclophosphamide (CYC), mycophenolate mofetil (MMF), methotrexate (MTX), and cyclosporine (CsA) in patients with systemic lupus erythematosus (SLE).
Thirty-eight publications were included.
Incidence of AEs ranged from 42.8% to 97.3%.
Common AEs included infections (2.4–77%), gastrointestinal AEs (3.2–66.7%), and amenorrhea and/or ovarian complications (0–71%).
More hematological cytopenias were associated with AZA (14 episodes) than MMF (2 episodes).
CYC was associated with more infections than MMF (40–77% versus 12.5–32%, resp.) or AZA (17–77% versus 11–29%, resp.).
Rates of hospitalized infections were similar between MMF and AZA patients, but higher for those taking CYC.
There were more gynecological toxicities with CYC than MMF (32–36% versus 3.6–6%, resp.) or AZA (32–71% versus 8–18%, resp.).
Discontinuation rates due to AEs were 0–44.4% across these medications.
In summary, the incidence of AEs associated with SLE immunosuppressants was consistently high as reported in the literature; discontinuations due to these AEs were similar across treatments.
Studies on the economic impact of these AEs were sparse and warrant further study.
This paper highlights the need for more treatment options with better safety profiles.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oglesby, A.& Shaul, A. J.& Pokora, T.& Paramore, C.& Cragin, L.& Dennis, G.…[et al.]. 2013. Adverse Event Burden, Resource Use, and Costs Associated with Immunosuppressant Medications for the Treatment of Systemic Lupus Erythematosus : A Systematic Literature Review. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464653
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oglesby, A.…[et al.]. Adverse Event Burden, Resource Use, and Costs Associated with Immunosuppressant Medications for the Treatment of Systemic Lupus Erythematosus : A Systematic Literature Review. International Journal of Rheumatology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-464653
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oglesby, A.& Shaul, A. J.& Pokora, T.& Paramore, C.& Cragin, L.& Dennis, G.…[et al.]. Adverse Event Burden, Resource Use, and Costs Associated with Immunosuppressant Medications for the Treatment of Systemic Lupus Erythematosus : A Systematic Literature Review. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464653
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464653
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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