Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct
المؤلفون المشاركون
Shores, Nathan J.
Kimbrell, Hillary Z.
Bratton, Laura
Weidenhaft, Mandy Crause
Nguyen, Jeremy
Wysocki, John
Agarwal, Rishi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-01
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Mixed adenoneuroendocrine carcinomas, spindle cell carcinomas, and clear cell carcinomas are all rare tumors in the biliary tract.
We present the first case, to our knowledge, of an extrahepatic bile duct carcinoma composed of all three types.
A 65-year-old man with prior cholecystectomy presented with painless jaundice, vomiting, and weight loss.
CA19-9 and alpha-fetoprotein (AFP) were elevated.
Cholangioscopy revealed a friable mass extending from the middle of the common bile duct to the common hepatic duct.
A bile duct excision was performed.
Gross examination revealed a 3.6 cm intraluminal polypoid tumor.
Microscopically, the tumor had foci of conventional adenocarcinoma (CK7-positive and CA19-9-postive) surrounded by malignant-appearing spindle cells that were positive for cytokeratins and vimentin.
Additionally, there were separate areas of large cell neuroendocrine carcinoma (LCNEC).
Foci of clear cell carcinoma merged into both the LCNEC and the adenocarcinoma.
Tumor invaded through the bile duct wall with extensive perineural and vascular invasion.
Circumferential margins were positive.
The patient’s poor performance status precluded adjuvant therapy and he died with recurrent and metastatic disease 5 months after surgery.
This is consistent with the reported poor survival rates of biliary mixed adenoneuroendocrine carcinomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wysocki, John& Agarwal, Rishi& Bratton, Laura& Nguyen, Jeremy& Weidenhaft, Mandy Crause& Shores, Nathan J.…[et al.]. 2014. Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-464687
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wysocki, John…[et al.]. Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct. Case Reports in Pathology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-464687
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wysocki, John& Agarwal, Rishi& Bratton, Laura& Nguyen, Jeremy& Weidenhaft, Mandy Crause& Shores, Nathan J.…[et al.]. Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-464687
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464687
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر