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A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds : Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition
المؤلفون المشاركون
Komohara, Yoshihiro
Fujiwara, Yukio
Takeya, Motohiro
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
There are many types of nontumor cells, including leukocytes, fibroblasts, and endothelial cells, in the tumor microenvironment.
Among these cells, infiltrating macrophages have recently received attention as novel target cells due to their protumoral functions.
Infiltrating macrophages are called tumor-associated macrophages (TAMs).
TAMs polarized to the M2 phenotype are involved in tumor development and are associated with a poor clinical prognosis.
Therefore, the regulation of TAM activation or M2 polarization is a new strategy for antitumor therapy.
We screened natural compounds possessing an inhibitory effect on the M2 polarization of human macrophages.
Among 200 purified natural compounds examined, corosolic acid (CA) and oleanolic acid (OA), both are categorized in triterpenoid compounds, inhibited macrophage polarization to M2 phenotype by suppressing STAT3 activation.
CA and OA also directly inhibited tumor cell proliferation and sensitized tumor cells to anticancer drugs, such as adriamycin and cisplatin.
The in vivo experiments showed that CA significantly suppressed subcutaneous tumor development and lung metastasis in a murine sarcoma model.
The application of triterpenoid compounds, such as CA and OA, is a potential new anticancer therapy targeting macrophage activation, with synergistic effects with anticancer agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fujiwara, Yukio& Takeya, Motohiro& Komohara, Yoshihiro. 2014. A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds : Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-464745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fujiwara, Yukio…[et al.]. A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds : Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-464745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fujiwara, Yukio& Takeya, Motohiro& Komohara, Yoshihiro. A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds : Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-464745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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