A Purified Recombinant Lipopeptide as Adjuvant for Cancer Immunotherapy
المؤلفون المشاركون
Chen, I-Hua
Song, Ying-Chyi
Leng, Chih-Hsiang
Chong, Pele
Liu, Shih-Jen
Chen, Hsin-Wei
Liu, Hsueh-Hung
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Synthetic lipopeptides have been widely used as vaccine adjuvants to enhance immune responses.
The present study demonstrated that the tryptic N-terminal fragment of the lipoprotein rlipo-D1E3 (lipo-Nter) induces superior antitumor effects compared to a synthetic lipopeptide.
The lipo-Nter was purified and formulated with protein or peptide vaccines to determine if lipo-Nter could be used as a novel adjuvant and could induce antitumor immunity in a cervical cancer model.
Purified lipo-Nter activated the maturation of bone marrow-derived dendritic cells (BM-DCs), leading to the secretion of TNF-α through TLR2/6 but not TLR1/2.
A recombinant mutant HPV16 E7 (rE7m) protein was mixed with lipo-Nter to immunize the mice; the anti-E7 antibody titers were increased, and the T helper cells were skewed toward the Th1 fate (increased IL-2 and decreased IL-5 secretion).
Single-dose injection of rE7m and lipo-Nter inhibited tumor growth, but the injection of rE7m alone did not.
Accordingly, lipo-Nter also enhanced the antitumor immunity of the E7-derived peptide but not the synthetic lipopeptide (Pam3CSK4).
We demonstrated that the lipo-Nter of a bacterial-derived recombinant lipoprotein is a novel adjuvant that could be used for the development of a new generation of vaccines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Ying-Chyi& Liu, Hsueh-Hung& Chen, I-Hua& Chen, Hsin-Wei& Chong, Pele& Leng, Chih-Hsiang…[et al.]. 2014. A Purified Recombinant Lipopeptide as Adjuvant for Cancer Immunotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-464866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Ying-Chyi…[et al.]. A Purified Recombinant Lipopeptide as Adjuvant for Cancer Immunotherapy. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-464866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Ying-Chyi& Liu, Hsueh-Hung& Chen, I-Hua& Chen, Hsin-Wei& Chong, Pele& Leng, Chih-Hsiang…[et al.]. A Purified Recombinant Lipopeptide as Adjuvant for Cancer Immunotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-464866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر