![](/images/graphics-bg.png)
Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties
المؤلفون المشاركون
Wilgenbus, Petra
Amort, Julianna
Schweikert, Eva-Maria
Horke, Sven
Teiber, John F.
Foerstermann, Ulrich
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The pathogen Pseudomonas aeruginosa causes serious damage in immunocompromised patients by secretion of various virulence factors, among them the quorum sensing N-(3-oxododecanoyl)-L-homoserine lactone (3OC12) and the redox-active pyocyanin (PCN).
Paraoxonase-2 (PON2) may protect against P.
aeruginosa infections, as it efficiently inactivates 3OC12 and diminishes PCN-induced oxidative stress.
This defense could be circumvented because 3OC12 mediates intracellular Ca2+-rise in host cells, which causes rapid inactivation and degradation of PON2.
Importantly, we recently found that the PON2 paralogue PON3 prevents mitochondrial radical formation.
Here we investigated its role as additional potential defense mechanism against P.
aeruginosa infections.
Our studies demonstrate that PON3 diminished PCN-induced oxidative stress.
Moreover, it showed clear anti-inflammatory potential by protecting against NF-κB activation and IL-8 release.
The latter similarly applied to PON2.
Furthermore, we observed a Ca2+-mediated inactivation and degradation of PON3, again in accordance with previous findings for PON2.
Our results suggest that the anti-oxidative and anti-inflammatory functions of PON2 and PON3 are an important part of our innate defense system against P.
aeruginosa infections.
Furthermore, we conclude that P.
aeruginosa circumvents PON3 protection by the same pathway as for PON2.
This may help identifying underlying mechanisms in order to sustain the protection afforded by these enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schweikert, Eva-Maria& Amort, Julianna& Wilgenbus, Petra& Foerstermann, Ulrich& Teiber, John F.& Horke, Sven. 2012. Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties. Journal of Lipids،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465178
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schweikert, Eva-Maria…[et al.]. Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties. Journal of Lipids No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-465178
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schweikert, Eva-Maria& Amort, Julianna& Wilgenbus, Petra& Foerstermann, Ulrich& Teiber, John F.& Horke, Sven. Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465178
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465178
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)