The Biochemistry and Regulation of S100A10 : A Multifunctional Plasminogen Receptor Involved in Oncogenesis

المؤلفون المشاركون

Madureira, Patricia A.
Waisman, David M.
Surette, Alexi P.
O'Connell, Paul A.
Miller, Victoria A.

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-21، 21ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-10-14

دولة النشر

مصر

عدد الصفحات

21

التخصصات الرئيسية

الطب البشري

الملخص EN

The plasminogen receptors mediate the production and localization to the cell surface of the broad spectrum proteinase, plasmin.

S100A10 is a key regulator of cellular plasmin production and may account for as much as 50% of cellular plasmin generation.

In parallel to plasminogen, the plasminogen-binding site on S100A10 is highly conserved from mammals to fish.

S100A10 is constitutively expressed in many cells and is also induced by many diverse factors and physiological stimuli including dexamethasone, epidermal growth factor, transforming growth factor-α, interferon-γ, nerve growth factor, keratinocyte growth factor, retinoic acid, and thrombin.

Therefore, S100A10 is utilized by cells to regulate plasmin proteolytic activity in response to a wide diversity of physiological stimuli.

The expression of the oncogenes, PML-RARα and KRas, also stimulates the levels of S100A10, suggesting a role for S100A10 in pathophysiological processes such as in the oncogenic-mediated increases in plasmin production.

The S100A10-null mouse model system has established the critical role that S100A10 plays as a regulator of fibrinolysis and oncogenesis.

S100A10 plays two major roles in oncogenesis, first as a regulator of cancer cell invasion and metastasis and secondly as a regulator of the recruitment of tumor-associated cells, such as macrophages, to the tumor site.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Madureira, Patricia A.& O'Connell, Paul A.& Surette, Alexi P.& Miller, Victoria A.& Waisman, David M.. 2012. The Biochemistry and Regulation of S100A10 : A Multifunctional Plasminogen Receptor Involved in Oncogenesis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-465237

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Madureira, Patricia A.…[et al.]. The Biochemistry and Regulation of S100A10 : A Multifunctional Plasminogen Receptor Involved in Oncogenesis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-465237

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Madureira, Patricia A.& O'Connell, Paul A.& Surette, Alexi P.& Miller, Victoria A.& Waisman, David M.. The Biochemistry and Regulation of S100A10 : A Multifunctional Plasminogen Receptor Involved in Oncogenesis. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-465237

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-465237