Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response
المؤلفون المشاركون
Tamura, Kenji
Hirakawa, Akihiro
Hamada, Chikuma
Fujiwara, Yasuhiro
Yonemori, Kan
Asano, Junichi
Hirata, Taizo
Shimizu, Chikako
المصدر
International Journal of Breast Cancer
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In prognostic studies for breast cancer patients treated with neoadjuvant chemotherapy (NAC), the ordinary Cox proportional-hazards (PH) model has been often used to identify prognostic factors for disease-free survival (DFS).
This model assumes that all patients eventually experience relapse or death.
However, a subset of NAC-treated breast cancer patients never experience these events during long-term follow-up (>10 years) and may be considered clinically “cured.” Clinical factors associated with cure have not been studied adequately.
Because the ordinary Cox PH model cannot be used to identify such clinical factors, we used the Cox PH cure model, a recently developed statistical method.
This model includes both a logistic regression component for the cure rate and a Cox regression component for the hazard for uncured patients.
The purpose of this study was to identify the clinical factors associated with cure and the variables associated with the time to recurrence or death in NAC-treated breast cancer patients without a pathologic complete response, by using the Cox PH cure model.
We found that hormone receptor status, clinical response, human epidermal growth factor receptor 2 status, histological grade, and the number of lymph node metastases were associated with cure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Asano, Junichi& Hirakawa, Akihiro& Hamada, Chikuma& Yonemori, Kan& Hirata, Taizo& Shimizu, Chikako…[et al.]. 2013. Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-465313
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Asano, Junichi…[et al.]. Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response. International Journal of Breast Cancer No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-465313
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Asano, Junichi& Hirakawa, Akihiro& Hamada, Chikuma& Yonemori, Kan& Hirata, Taizo& Shimizu, Chikako…[et al.]. Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-465313
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465313
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر