Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response
Joint Authors
Tamura, Kenji
Hirakawa, Akihiro
Hamada, Chikuma
Fujiwara, Yasuhiro
Yonemori, Kan
Asano, Junichi
Hirata, Taizo
Shimizu, Chikako
Source
International Journal of Breast Cancer
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In prognostic studies for breast cancer patients treated with neoadjuvant chemotherapy (NAC), the ordinary Cox proportional-hazards (PH) model has been often used to identify prognostic factors for disease-free survival (DFS).
This model assumes that all patients eventually experience relapse or death.
However, a subset of NAC-treated breast cancer patients never experience these events during long-term follow-up (>10 years) and may be considered clinically “cured.” Clinical factors associated with cure have not been studied adequately.
Because the ordinary Cox PH model cannot be used to identify such clinical factors, we used the Cox PH cure model, a recently developed statistical method.
This model includes both a logistic regression component for the cure rate and a Cox regression component for the hazard for uncured patients.
The purpose of this study was to identify the clinical factors associated with cure and the variables associated with the time to recurrence or death in NAC-treated breast cancer patients without a pathologic complete response, by using the Cox PH cure model.
We found that hormone receptor status, clinical response, human epidermal growth factor receptor 2 status, histological grade, and the number of lymph node metastases were associated with cure.
American Psychological Association (APA)
Asano, Junichi& Hirakawa, Akihiro& Hamada, Chikuma& Yonemori, Kan& Hirata, Taizo& Shimizu, Chikako…[et al.]. 2013. Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-465313
Modern Language Association (MLA)
Asano, Junichi…[et al.]. Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response. International Journal of Breast Cancer No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-465313
American Medical Association (AMA)
Asano, Junichi& Hirakawa, Akihiro& Hamada, Chikuma& Yonemori, Kan& Hirata, Taizo& Shimizu, Chikako…[et al.]. Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-465313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465313