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Drosophila Answers to TDP-43 Proteinopathies
المؤلفون المشاركون
Feiguin, Fabian
Romano, Maurizio
Buratti, Emanuele
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Initially implicated in the pathogenesis of CFTR and HIV-1 transcription, nuclear factor TDP-43 was subsequently found to be involved in the origin and development of several neurodegenerative diseases.
In 2006, in fact, it was reported for the first time the cytoplasmic accumulation of TDP-43 in ubiquitin-positive inclusions of ALS and FTLD patients, suggesting the presence of a shared underlying mechanism for these diseases.
Today, different animal models of TDP-43 proteinopathies are available in rodents, nematodes, fishes, and flies.
Although these models recapitulate several of the pathological features found in patients, the mechanisms underpinning the progressive neuronal loss observed in TDP-43 proteinopathies remain to be characterized.
Compared to other models, Drosophila are appealing because they combine the presence of a sophisticated brain with the possibility to investigate quickly and massively phenotypic genetic modifiers as well as possible therapeutic strategies.
At present, the development of TDP-43-related Drosophila models has further strengthened the hypothesis that both TDP-43 “loss-of-function” and “gain-of-function” mechanisms can contribute to disease.
The aim of this paper is to describe and compare the results obtained in a series of transgenic and knockout flies, along with the information they have generated, towards a better understanding of the mechanisms underlying TDP-43 proteinopathies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Romano, Maurizio& Feiguin, Fabian& Buratti, Emanuele. 2012. Drosophila Answers to TDP-43 Proteinopathies. Journal of Amino Acids،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-465372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Romano, Maurizio…[et al.]. Drosophila Answers to TDP-43 Proteinopathies. Journal of Amino Acids No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-465372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Romano, Maurizio& Feiguin, Fabian& Buratti, Emanuele. Drosophila Answers to TDP-43 Proteinopathies. Journal of Amino Acids. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-465372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465372
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