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The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients
المؤلفون المشاركون
al-Zoghaibi, Fahad
Albenmousa, Ali
al-Anazi, Mashael R.
al-Qahtani, Ahmed A.
al-Ashgar, Hamad I.
Sanai, Faisal M.
al-Ahdal, Muhammad N.
Khan, Mohammed Q.
Abdo, Ayman A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hepatitis C virus (HCV) is a single stranded RNA virus.
It affects millions of people worldwide and is considered as a leading cause of liver diseases including cirrhosis and hepatocellular carcinoma.
A recent study reported that TLR4 gene polymorphisms are good prognostic predictors and are associated with protection from liver fibrosis among Caucasians.
This study aims to investigate the implication of genetic polymorphisms of TLR4 gene on the HCV infection in Saudi Arabian patients.
Two SNPs in the TLR4 gene, rs4986790 (A/G) and rs4986791 (C/T), were genotyped in 450 HCV patients and 600 uninfected controls.
The association analysis confirmed that both SNPs showed a significant difference in their distribution between HCV-infected patients and uninfected control subjects (P<0.0001; OR=0.404, 95% CI=0.281–0.581) and (P<0.0001; OR=0.298, 95% CI=0.201–0.443), respectively.
More importantly, haplotype analysis revealed that four haplotypes, AC, GT, GC, and AT (rs4986790, rs4986791), were significantly associated with HCV infection when compared with control subjects.
One haplotype AC was more prominently found when chronic HCV-infected patients were compared with cirrhosis/HCC patients (frequency = 94.7% and P=0.04).
Both TLR4 SNPs under investigation were found to be significantly implicated with HCV-infection among Saudi Arabian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Qahtani, Ahmed A.& al-Anazi, Mashael R.& al-Zoghaibi, Fahad& Abdo, Ayman A.& Sanai, Faisal M.& Khan, Mohammed Q.…[et al.]. 2014. The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-465486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Qahtani, Ahmed A.…[et al.]. The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-465486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Qahtani, Ahmed A.& al-Anazi, Mashael R.& al-Zoghaibi, Fahad& Abdo, Ayman A.& Sanai, Faisal M.& Khan, Mohammed Q.…[et al.]. The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-465486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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