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Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat
المؤلفون المشاركون
Tobin, Gunnar
Vesela, Renata
Winder, Michael
Tayem, Yasin I.
Johnsson, Martin
Wsol, Vladimir
Aronsson, Patrik
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nitric oxide (NO) has pivotal roles in cyclophosphamide- (CYP-) induced cystitis during which mucosal nitric oxide synthase (NOS) and muscarinic M5 receptor expressions are upregulated.
In cystitis, urothelial muscarinic NO-linked effects hamper contractility.
Therefore we wondered if a blockade of this axis also affects the induction of cystitis in the rat.
Rats were pretreated with saline, the muscarinic receptor antagonist 4-DAMP (1 mg/kg ip), or the NOS inhibitor L-NAME (30 mg/kg ip) for five days.
60 h before the experiments the rats were treated with saline or CYP.
Methacholine-, ATP-, and adenosine-evoked responses were smaller in preparations from CYP-treated rats than from saline-treated ones.
Pretreatment with 4-DAMP did not change this relation, while pretreatment with L-NAME normalized the responses in the CYP-treated animals.
The functional results were strengthened by the morphological observations; 4-DAMP pretreatment did not affect the parameters studied, namely, expression of muscarinic M5 receptors, P1A1 purinoceptors, mast cell distribution, or bladder wall enlargement.
However, pretreatment with L-NAME attenuated the differences.
Thus, the current study provides new insights into the complex mechanisms behind CYP-induced cystitis.
The NO effects coupled to urothelial muscarinic receptors have a minor role in the development of cystitis.
Inhibition of NOS may prevent the progression of cystitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aronsson, Patrik& Vesela, Renata& Johnsson, Martin& Tayem, Yasin I.& Wsol, Vladimir& Winder, Michael…[et al.]. 2014. Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-465687
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aronsson, Patrik…[et al.]. Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-465687
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aronsson, Patrik& Vesela, Renata& Johnsson, Martin& Tayem, Yasin I.& Wsol, Vladimir& Winder, Michael…[et al.]. Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-465687
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465687
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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