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Differences in Cytotoxic, Genotoxic, and Inflammatory Response of Bronchial and Alveolar Human Lung Epithelial Cells to Pristine and COOH-Functionalized Multiwalled Carbon Nanotubes
المؤلفون المشاركون
Fresegna, Anna Maria
Ciervo, Aureliano
Ursini, Cinzia Lucia
Cavallo, Delia
Casciardi, Stefano
Buresti, Giuliana
Maiello, Raffaele
Bellucci, Stefano
Iavicoli, Sergio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Functionalized MWCNTs are used in many commercial and biomedical applications, but their potential health effects are not well defined.
We investigated and compared cytotoxic, genotoxic/oxidative, and inflammatory effects of pristine and carboxyl MWCNTs exposing human respiratory (A549 and BEAS-2B) cells to 1–40 μg/mL of CNTs for 24 h.
Both MWCNTs induced low viability reduction (by WST1 assay) in A549 cells and only MWCNTs-COOH caused high viability reduction in BEAS-2B cells reaching 28.5% viability at 40 μg/mL.
Both CNTs induced membrane damage (by LDH assay) with higher effects in BEAS-2B cells at the highest concentrations reaching 20% cytotoxicity at 40 μg/mL.
DNA damage (by Fpg-comet assay) was induced by pristine MWCNTs in A549 cells and by both MWCNTs in BEAS-2B cells reaching for MWCNTs-COOH a tail moment of 22.2 at 40 μg/mL versus 10.2 of unexposed cells.
Increases of IL-6 and IL-8 release (by ELISA) were detected in A549 cells exposed to MWCNTs-COOH from 10 μg/mL while IL-8 increased in BEAS-2B cells exposed to pristine MWCNTs at 20 and 40 μg/mL.
The results show higher cytogenotoxicity of MWCNTs-COOH in bronchial and of pristine MWCNTs in alveolar cells.
Different inflammatory response was also found.
The findings suggest the use of in vitro models with different end points and cells to study CNT toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ursini, Cinzia Lucia& Cavallo, Delia& Fresegna, Anna Maria& Ciervo, Aureliano& Maiello, Raffaele& Buresti, Giuliana…[et al.]. 2014. Differences in Cytotoxic, Genotoxic, and Inflammatory Response of Bronchial and Alveolar Human Lung Epithelial Cells to Pristine and COOH-Functionalized Multiwalled Carbon Nanotubes. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-465729
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ursini, Cinzia Lucia…[et al.]. Differences in Cytotoxic, Genotoxic, and Inflammatory Response of Bronchial and Alveolar Human Lung Epithelial Cells to Pristine and COOH-Functionalized Multiwalled Carbon Nanotubes. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-465729
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ursini, Cinzia Lucia& Cavallo, Delia& Fresegna, Anna Maria& Ciervo, Aureliano& Maiello, Raffaele& Buresti, Giuliana…[et al.]. Differences in Cytotoxic, Genotoxic, and Inflammatory Response of Bronchial and Alveolar Human Lung Epithelial Cells to Pristine and COOH-Functionalized Multiwalled Carbon Nanotubes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-465729
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465729
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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