Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis
المؤلفون المشاركون
Park, Yong-Soo
Kim, Dong-Hyun
Park, Kyung-Ho
Jeon, Eun-ju
Yeo, Sang Won
Park, Shi-Nae
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This prospective, randomized, and controlled study examined the effects of tumor necrosis factor soluble receptor type I (sTNFRI, a TNF-α antagonist) on experimentally induced rhinosinusitis in rats.
The experimental groups received an instillation of lipopolysaccharide (LPS) plus an intramuscular injection of amoxicillin/clavulanate (antibiotic group), an instillation of sTNFRI (sTNFRI group), an instillation of sTNFRI and an injection of amoxicillin/clavulanate (sTNFRI/antibiotic group), or no additional treatment (LPS group).
Histopathological changes were determined using hematoxylin-eosin and periodic acid-Schiff (PAS) staining.
Leakage of exudate was determined using fluorescence microscopy.
Vascular permeability was measured using the Evans blue dye technique.
Expression of MUC5AC was measured using reverse transcriptase PCR.
The sTNFRI, antibiotic, and sTNFRI/antibiotic groups had significantly less capillary permeability, mucosal edema, PAS staining, and expression of MUC5AC than the LPS group.
There were no differences in capillary permeability, mucosal edema, PAS staining, and MUC5AC expression between the sTNFRI and sTNFRI/antibiotic groups.
The antibiotic group had PAS staining similar to that of the sTNFRI and sTNFRI/antibiotic groups but had a greater increase in capillary permeability, mucosal edema, and MUC5AC expression.
This study shows that sTNFRI reduces inflammatory activity and mucus hypersecretion in LPS-induced rhinosinusitis in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Dong-Hyun& Jeon, Eun-ju& Park, Shi-Nae& Park, Kyung-Ho& Park, Yong-Soo& Yeo, Sang Won. 2011. Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-465808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Dong-Hyun…[et al.]. Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-465808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Dong-Hyun& Jeon, Eun-ju& Park, Shi-Nae& Park, Kyung-Ho& Park, Yong-Soo& Yeo, Sang Won. Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-465808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر