Lomustine Analogous Drug Structures for Intervention of Brain and Spinal Cord Tumors : The Benefit of In Silico Substructure Search and Analysis
المؤلف
المصدر
Chemotherapy Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Lomustine is a nitrosourea anticancer agent shown to be effective for treatment of childhood medulloblastoma.
In silico substructure searches produced 17 novel nitrosourea agents analogous to lumustine and retaining activity for DNA alkylation and cytotoxic activity.
The mean values for Log P, polar surface area, formula weight, number of oxygens & nitrogens, and rotatable bonds were 2.524, 62.89 Anstroms2, 232.8, 5, and 2, respectively.
All 17 agents have formula weight less than 450 and Log P less than 5, two criteria preferred for blood-brain barrier penetration.
These agents have a polar surface area less than 90 Angstroms2.
Each show zero violations of the Rule of five indicating favorable drug likeness and oral drug activity.
Hierarchical cluster analysis indicated that 16 of the novel agents were highly similar to lomustine, save for agent 12 which bears a hydroxylated branched carbon substituent.
A total of 17 novel anticancer agents were elucidated having molecular properties very effective for penetrating through the BBB and into the central nervous system.
This study shows the effectiveness of in silico search and recognition of anticancer agents that are suitable for the clinical treatment of brain tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bartzatt, Ronald. 2013. Lomustine Analogous Drug Structures for Intervention of Brain and Spinal Cord Tumors : The Benefit of In Silico Substructure Search and Analysis. Chemotherapy Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465821
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bartzatt, Ronald. Lomustine Analogous Drug Structures for Intervention of Brain and Spinal Cord Tumors : The Benefit of In Silico Substructure Search and Analysis. Chemotherapy Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-465821
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bartzatt, Ronald. Lomustine Analogous Drug Structures for Intervention of Brain and Spinal Cord Tumors : The Benefit of In Silico Substructure Search and Analysis. Chemotherapy Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465821
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465821
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر