Polymorphisms in HSD17B1 : Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome
المؤلفون المشاركون
Tycko, Benjamin
Janicki, Sarah C.
Park, Naeun
Silverman, Wayne
Zigman, Warren B.
Schupf, Nicole
Lee, Joseph H.
Temkin, Alexis
Pang, Deborah
Gurney, Susan
المصدر
Current Gerontology and Geriatrics Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background/Aims.
Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD).
In women with Down syndrome, we examined the relation of polymorphisms in hydroxysteroid-17beta-dehydrogenase (HSD17B1) to age at onset and risk of AD.
HSD17B1 encodes the enzyme 17β-hydroxysteroid dehydrogenase (HSD1), which catalyzes the conversion of estrone to estradiol.
Methods.
Two hundred and thirty-eight women with DS, nondemented at baseline, 31–78 years of age, were followed at 14–18-month intervals for 4.5 years.
Women were genotyped for 5 haplotype-tagging single-nucleotide polymorphisms (SNPs) in the HSD17B1 gene region, and their association with incident AD was examined.
Results.
Age at onset was earlier, and risk of AD was elevated from two- to threefold among women homozygous for the minor allele at 3 SNPs in intron 4 (rs676387), exon 6 (rs605059), and exon 4 in COASY (rs598126).
Carriers of the haplotype TCC, based on the risk alleles for these three SNPs, had an almost twofold increased risk of developing AD (hazard ratio = 1.8, 95% CI, 1.1–3.1).
Conclusion.
These findings support experimental and clinical studies of the neuroprotective role of estrogen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Joseph H.& Gurney, Susan& Pang, Deborah& Temkin, Alexis& Park, Naeun& Janicki, Sarah C.…[et al.]. 2012. Polymorphisms in HSD17B1 : Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Joseph H.…[et al.]. Polymorphisms in HSD17B1 : Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-465866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Joseph H.& Gurney, Susan& Pang, Deborah& Temkin, Alexis& Park, Naeun& Janicki, Sarah C.…[et al.]. Polymorphisms in HSD17B1 : Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-465866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر