Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds
المؤلفون المشاركون
Qu, Hai-bin
Zhou, Chenguang
Wang, Yi
Xu, Dongmei
Hong, Chengtao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Psoralea corylifolia L.
(Fabaceae) is a widely used medical plant in China.
This study was designed to screen and identify bioactive compounds with anticancer activity from the seeds of Psoralea corylifolia L.
One volatile fraction (fraction I) and three other fractions (fraction II, III, IV) from methanol extraction of P.
corylifolia L.
were obtained.
Bioactivities of these fractions were evaluated by the cytotoxicity on KB, KBv200, K562, K562/ADM cancer cells with MTT assay.
Major components in the active fraction were identified by HPLC/MSn.
Fraction IV significantly inhibits the growth of cancer cells in a dose-dependent manner.
The IC50 values were 21.6, 24.4, 10.0 and 26.9, respectively.
Psoralen and isopsoralen, isolated from fraction IV, were subject to bioactive assay and presented a dose-dependent anticancer activity in four cancer cell lines (KB, KBv200, K562 and K562/ADM).
The IC50 values of psoralen were 88.1, 86.6, 24.4 and 62.6, which of isopsoralen were 61.9, 49.4, 49.6 and 72.0, respectively.
Apoptosis of tumor cell significantly increased after treated with psoralen and isopsoralen.
Induction of apoptotic activity was confirmed by flow cytometry after staining with Annexin V/PI.
These results suggested psoralen and isopsoralen contribute to anticancer effect of P.
corylifolia L.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yi& Hong, Chengtao& Zhou, Chenguang& Xu, Dongmei& Qu, Hai-bin. 2011. Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466044
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yi…[et al.]. Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-466044
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yi& Hong, Chengtao& Zhou, Chenguang& Xu, Dongmei& Qu, Hai-bin. Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466044
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466044
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر