MYD88 L265P Mutations Are Correlated with 6q Deletion in Korean Patients with Waldenström Macroglobulinemia
المؤلفون المشاركون
Lee, Dong Soon
Im, Kyongok
Hwang, Sang Mee
Sekiguchi, Naohiro
Park, Si Nae
Yoon, Sung-Soo
Choi, Qute
Kim, Jung-Ah
Kim, Seon Young
Kwon, Jiseok
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Waldenström macroglobulinemia (WM) is a malignant lymphoplasma-proliferative disorder with IgM monoclonal gammopathy.
A recent whole-genome study identified MYD88 L265P as the key mutation in WM.
We investigated MYD88 mutations in conjunction with cytogenetic study in 22 consecutive Korean WM patients.
Conventional G-banding and interphase fluorescence in situ hybridization (FISH) were performed at regions including 6q21 using bone marrow (BM) aspirates.
Sixteen patients were subjected to Sanger sequencing-based MYD88 mutation study.
Five patients (28%) showed cytogenetic aberrations in G-banding.
The incidence of 6q21 deletion was 17% by conventional G-banding and 37% by FISH.
Ten patients (45%) showed cytogenetic aberrations using FISH: 6q deletion in eight (37%) and IGH rearrangement in four (18%).
Two patients had both the 6q deletion and IGH rearrangement, and two had only the IGH rearrangement.
Eleven patients (69%) presented with the MYD88 L265P mutation.
MYD88 mutations were significantly associated with the presence of 6q deletions (P=0.037).
Six patients with the 6q deletion for whom sequencing was possible were found to harbor MYD88 mutations.
The MYD88 L265P mutation was also associated with increased lymphocyte burden in BM biopsy.
This is the first report of high frequency MYD88 L265P mutations in Korean WM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Jung-Ah& Im, Kyongok& Park, Si Nae& Kwon, Jiseok& Choi, Qute& Hwang, Sang Mee…[et al.]. 2014. MYD88 L265P Mutations Are Correlated with 6q Deletion in Korean Patients with Waldenström Macroglobulinemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Jung-Ah…[et al.]. MYD88 L265P Mutations Are Correlated with 6q Deletion in Korean Patients with Waldenström Macroglobulinemia. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-466069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Jung-Ah& Im, Kyongok& Park, Si Nae& Kwon, Jiseok& Choi, Qute& Hwang, Sang Mee…[et al.]. MYD88 L265P Mutations Are Correlated with 6q Deletion in Korean Patients with Waldenström Macroglobulinemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر