Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients
المؤلفون المشاركون
Mashhadi, Mohamad Ali
Sanadgol, Hoshang
Shakiba, Mansor
Sharifi, Hassan
Azmoude, Hamid Reza
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it.
This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus.
Methods.
19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial.
Before and after starting treatment with sertraline, a detailed pruritus history was obtained and pruritus graded by the 30-item inventory of pruritus that patients based on priorities grade allocated to 3 classes.
Subjects were treated with sertraline 50 mg oral daily for four months, with monthly assessments of pruritus symptoms.
Results.
Before treatment with sertraline, the grade of pruritus in 9 (47.4%) patients was moderate and severe in 10 (52.6%) patients.
After treatment, grade of pruritus in 11 (57.8%) patients was weak, 6 (31.5%) have moderate and only 2 (10.7%) patients have severe pruritus.
Of 10 patients with severe pruritus, 5 (50%) patients experiencing weak pruritus, and 4 (40%) patients have moderate pruritus after treatment.
Based on Wilcoxon signed-rank test, the difference between the grade of pruritus before and after treatment with sertraline was significant (P=0.001).
Conclusions.
Although no definitive recommendation can be made regarding treatment of uremic pruritus, we found an increased antipruritic effect of sertraline in ESRD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shakiba, Mansor& Sanadgol, Hoshang& Azmoude, Hamid Reza& Mashhadi, Mohamad Ali& Sharifi, Hassan. 2012. Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-466097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shakiba, Mansor…[et al.]. Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients. International Journal of Nephrology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-466097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shakiba, Mansor& Sanadgol, Hoshang& Azmoude, Hamid Reza& Mashhadi, Mohamad Ali& Sharifi, Hassan. Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-466097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر