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Cardioprotective Effects of Quercetin in Cardiomyocyte under IschemiaReperfusion Injury
المؤلفون المشاركون
Chan, Hong-Lin
Lin, Szu-Ting
Chen, You-Hsuan
Chang, Yu-Jung
Chen, Yi-Wen
Chen, Linyi
Chou, Hsiu-Chuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-14
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Quercetin, a polyphenolic compound existing in many vegetables, fruits, has antiinflammatory, antiproliferation, and antioxidant effect on mammalian cells.
Quercetin was evaluated for protecting cardiomyocytes from ischemia/reperfusion injury, but its protective mechanism remains unclear in the current study.
The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression.
Fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can reveal the differentially expressed proteins of H9C2 cells treated with H2O2 or quercetin.
Although 17 identified proteins were altered in H2O2-induced cells, these proteins such as alpha-soluble NSF attachment protein (α-SNAP), Ena/VASP-like protein (Evl), and isopentenyl-diphosphate delta-isomerase 1 (Idi-1) were reverted by pretreatment with quercetin, which correlates with kinase activation, DNA repair, lipid, and protein metabolism.
Quercetin dephosphorylates Src kinase in H2O2-induced H9C2 cells and likely blocks the H2O2-induced inflammatory response through STAT3 kinase modulation.
This probably contributes to prevent ischemia/reperfusion injury in cardiomyocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yi-Wen& Chou, Hsiu-Chuan& Lin, Szu-Ting& Chen, You-Hsuan& Chang, Yu-Jung& Chen, Linyi…[et al.]. 2013. Cardioprotective Effects of Quercetin in Cardiomyocyte under IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-466153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yi-Wen…[et al.]. Cardioprotective Effects of Quercetin in Cardiomyocyte under IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-466153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yi-Wen& Chou, Hsiu-Chuan& Lin, Szu-Ting& Chen, You-Hsuan& Chang, Yu-Jung& Chen, Linyi…[et al.]. Cardioprotective Effects of Quercetin in Cardiomyocyte under IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-466153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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