Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
المؤلفون المشاركون
Santos-Oliveira, Joanna R.
Da-Cruz, Alda Maria
المصدر
International Journal of Microbiology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-22
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
الملخص EN
Visceral Leishmaniasis (VL) is an infectious disease which constitutes a serious public health problem, integrating the list of neglected tropical diseases.
The disease is characterized by a Leishmania-specific immune suppression T-cell depletion and a decrease of other hematopoietic cells.
In parallel, an immunostimulatory response also occurs, represented by polyclonal B lymphocytes, T-cell activation, and systemic proinflammatory responses.
Parasite antigens were believed to mediate both suppression and activation mechanisms, but these concepts are constantly being revised.
Similar to reports on HIV/AIDS, we have proposed that gut parasitation by amastigotes and lymphocyte depletion could also affect gut-associated lymphoid tissue, leading to mucosal barrier breach and predisposing to microbial translocation.
An increment of plasmatic lipopolysaccharide (LPS) levels observed in Brazilian VL patients was implicated in the reduced blood CD4+ and CD8+ T cell counts, systemic T-cell activation, pro-inflammatory cytokines and MIF plasma levels, suggesting that a bacterial molecule not associated with Leishmania infection can exert deleterious effects on immune system.
Recent results also pointed that the proinflammatory response was potentiated in VL/HIV-AIDS coinfected patients.
The LPS-mediated cell activation adds another concept to the immunopathogenesis of VL and can bring a rational for new therapeutic interventions that could ameliorate the management of these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos-Oliveira, Joanna R.& Da-Cruz, Alda Maria. 2012. Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-466157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos-Oliveira, Joanna R.& Da-Cruz, Alda Maria. Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. International Journal of Microbiology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-466157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos-Oliveira, Joanna R.& Da-Cruz, Alda Maria. Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. International Journal of Microbiology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-466157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر