Superoxide Dismutase1 Levels in North Indian Population with Age-Related Macular Degeneration
المؤلفون المشاركون
Sharma, Suresh K.
Prabhakar, Sudesh
Gupta, Amod
Sharma, Neel K.
Singh, Ramandeep
Anand, Akshay
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Aim.
The aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD.
Methods.
115 AMD patients and 61 healthy controls were recruited for this study.
Serum SOD1 levels were determined by ELISA and were correlated to various risk factors.
Logistic regression model of authenticity, by considering SOD1 as independent variable, has been developed along with ROC curve.
Results.
The SOD1 levels were significantly higher in AMD patients as compared to those of the controls.
The difference was not significant for wet and dry AMD.
However, the difference was significant between wet AMD subtypes.
Nonsignificance of the Hosmer-Lemeshow goodness of fit statistic (χ2=10.516, df=8, P=0.231) indicates the appropriateness of logistic regression model to predict AMD.
Conclusion.
Oxidative stress in AMD patients may mount compensatory response resulting in increased levels of SOD1 in AMD patients.
To predict the risk of AMD on the basis of SOD1, a logistic regression model shows authenticity of 78%, and area under the ROC curve (0.827, P=.0001) with less standard error of 0.033 coupled with 95% confidence interval of 0.762–0.891 further validates the model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Anand, Akshay& Sharma, Neel K.& Gupta, Amod& Prabhakar, Sudesh& Sharma, Suresh K.& Singh, Ramandeep. 2013. Superoxide Dismutase1 Levels in North Indian Population with Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-466207
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Anand, Akshay…[et al.]. Superoxide Dismutase1 Levels in North Indian Population with Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-466207
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Anand, Akshay& Sharma, Neel K.& Gupta, Amod& Prabhakar, Sudesh& Sharma, Suresh K.& Singh, Ramandeep. Superoxide Dismutase1 Levels in North Indian Population with Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-466207
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466207
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر