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Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression
المؤلفون المشاركون
Cui, Wei
Muddasani, Ramya
Lu, Gary
Bueso-Ramos, Carlos E.
Sun, Jianlan
Chen, Su S.
Yin, C. Cameron
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Trisomy 14 is a rare recurrent cytogenetic abnormality in myeloid neoplasms; however, its clinicopathologic features have not been well described.
We report the clinicopathologic, immunophenotypic, and molecular genetic features of 16 cases of myeloid neoplasms with isolated trisomy 14.
Our results show that cases with isolated trisomy 14 encompass a heterogenous group of myeloid neoplasms including myelodysplastic syndrome (MDS, 44%), myelodysplastic/myeloproliferative neoplasms (31%), and acute myeloid leukemia (25%).
The patients are usually elder (median age 71 years), and there is a male predominance (82%).
Multilineage dysplasia is noted in all cases.
Oncogenic mutations of genes involved in cell proliferation and/or survival rarely occur.
Compared with cases of MDS with diploid karyotype, patients of MDS with isolated trisomy 14 demonstrate a similar overall survival and rate of leukemia transformation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Wei& Bueso-Ramos, Carlos E.& Yin, C. Cameron& Sun, Jianlan& Chen, Su S.& Muddasani, Ramya…[et al.]. 2011. Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-466244
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Wei…[et al.]. Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-466244
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Wei& Bueso-Ramos, Carlos E.& Yin, C. Cameron& Sun, Jianlan& Chen, Su S.& Muddasani, Ramya…[et al.]. Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression. Journal of Biomedicine and Biotechnology. 2011. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-466244
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466244
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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