Rapid Screening of Novel Agents for Combination Therapy in Sarcomas
المؤلفون المشاركون
Sullivan, Daniel M.
Bui, Marilyn M.
Martinez, Gary V.
Menth, Jiliana
Dawson, Jana
Reed, Damon R.
Cubitt, Christopher L.
Letson, G. Douglas
Foroutan, Parastou
Morse, David L.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
For patients with sarcoma, metastatic disease remains very difficult to cure, and outcomes remain less than optimal.
Treatment options have not largely changed, although some promising gains have been made with single agents in specific subtypes with the use of targeted agents.
Here, we developed a system to investigate synergy of combinations of targeted and cytotoxic agents in a panel of sarcoma cell lines.
Agents were investigated alone and in combination with varying dose ratios.
Dose-response curves were analyzed for synergy using methods derived from Chou and Talalay (1984).
A promising combination, dasatinib and triciribine, was explored in a murine model using the A673 cell line, and tumors were evaluated by MRI and histology for therapy effect.
We found that histone deacetylase inhibitors were synergistic with etoposide, dasatinib, and Akt inhibitors across cell lines.
Sorafenib and topotecan demonstrated a mixed response.
Our systematic drug screening method allowed us to screen a large number of combinations of sarcoma agents.
This method can be easily modified to accommodate other cell line models, and confirmatory assays, such as animal experiments, can provide excellent preclinical data to inform clinical trials for these rare malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cubitt, Christopher L.& Menth, Jiliana& Dawson, Jana& Martinez, Gary V.& Foroutan, Parastou& Morse, David L.…[et al.]. 2013. Rapid Screening of Novel Agents for Combination Therapy in Sarcomas. Sarcoma،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-466281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cubitt, Christopher L.…[et al.]. Rapid Screening of Novel Agents for Combination Therapy in Sarcomas. Sarcoma No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-466281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cubitt, Christopher L.& Menth, Jiliana& Dawson, Jana& Martinez, Gary V.& Foroutan, Parastou& Morse, David L.…[et al.]. Rapid Screening of Novel Agents for Combination Therapy in Sarcomas. Sarcoma. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-466281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر