In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca : Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase
المؤلفون المشاركون
Pommerening, Tanja
Maniako, Rudeka
Deininger, Susanne
Kusch, Peter
Haubrich, Stefanie
Kaiser, Annette
Specht, Sabine
Lin, Paul Kong Thoo
Hoerauf, Achim
المصدر
Journal of Parasitology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Balanites aegyptiaca (Balanitaceae) is a widely grown desert plant with multiuse potential.
In the present paper, a crude extract from B.
aegyptiaca seeds equivalent to a ratio of 1 : 2000 seeds to the extract was screened for antiplasmodial activity.
The determined IC50 value for the chloroquine-susceptible Plasmodium falciparum NF54 strain was 68.26 μg/μL±3.5.
Analysis of the extract by gas chromatography-mass spectrometry detected 6-phenyl-2(H)-1,2,4-triazin-5-one oxime, an inhibitor of the parasitic M18 Aspartyl Aminopeptidase as one of the compounds which is responsible for the in vitro antiplasmodial activity.
The crude plant extract had a Ki of 2.35 μg/μL and showed a dose-dependent response.
After depletion of the compound, a significantly lower inhibition was determined with a Ki of 4.8 μg/μL.
Moreover, two phenolic compounds, that is, 2,6-di-tert-butyl-phenol and 2,4-di-tert-butyl-phenol, with determined IC50 values of 50.29 μM±3 and 47.82 μM±2.5, respectively, were detected.
These compounds may contribute to the in vitro antimalarial activity due to their antioxidative properties.
In an in vivo experiment, treatment of BALB/c mice with the aqueous Balanite extract did not lead to eradication of the parasites, although a reduced parasitemia at day 12 p.i.
was observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kusch, Peter& Deininger, Susanne& Specht, Sabine& Maniako, Rudeka& Haubrich, Stefanie& Pommerening, Tanja…[et al.]. 2011. In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca : Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-466491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kusch, Peter…[et al.]. In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca : Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase. Journal of Parasitology Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-466491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kusch, Peter& Deininger, Susanne& Specht, Sabine& Maniako, Rudeka& Haubrich, Stefanie& Pommerening, Tanja…[et al.]. In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca : Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-466491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر