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Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis
المؤلفون المشاركون
Yamaguchi, Yoshiki
Mori, Tsutomu
Kato, Masaki
Kuroda, Masahito
Kochi, Hideo
Ohira, Hiromasa
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs) that react with the lipoyl-containing E2 subunits of 2-oxoacid dehydrogenase complexes such as BCOADC and PDC.
The lipoyl domains of E2 contain the major epitopes essential for immunopathology.
However, the non-lipoyl-containing E1 subunits are also frequently targeted.
Since anti-E1 antibodies always appear in combination with anti-E2 antibodies, the mechanisms underlying the autoimmunity against E1 may be linked to, but distinct from, those against E2.
Here, we demonstrate that intermolecular and intramolecular determinant spreading underlies the autoimmunity against E1.
We performed characterizations and epitope mapping for anti-BCOADC-E1α antibodies from both the intermolecular and intramolecular points of view.
The antibody reactivities form a cluster against the BCOADC complex that is distinct from that against the PDC complex, and the anti-BCOADC-E1α antibodies arise as part of the cluster against the BCOADC complex.
Multiple epitopes are present on the surface of the BCOADC-E1α molecule, and the major epitope overlaps with the active center.
Sera with anti-BCOADC-E1α antibodies strongly inhibited the enzyme activity.
These findings suggest that the E1α subunit as part of the native BCOADC complex is an immunogen, and that determinant spreading is involved in the pathogenesis of AMA production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mori, Tsutomu& Ohira, Hiromasa& Kuroda, Masahito& Kato, Masaki& Yamaguchi, Yoshiki& Kochi, Hideo. 2012. Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466599
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mori, Tsutomu…[et al.]. Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis. International Journal of Hepatology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-466599
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mori, Tsutomu& Ohira, Hiromasa& Kuroda, Masahito& Kato, Masaki& Yamaguchi, Yoshiki& Kochi, Hideo. Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466599
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466599
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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