Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy
المؤلفون المشاركون
Matheu, Víctor
Sánchez-Machín, Inmaculada
Zapatero, Lydia
Franco, Andres
Infante, Sonsoles
Barrios, Yvelise
Alonso, Elena
González Pérez, Ruperto
Fuentes, Victoria
Poza-Guedes, Paloma
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF).
The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy.
Methods.
We design a prospective longitudinal study (n=30) with patients with persistent cow’s milk proteins (CMP) allergy.
After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th1, Th2, Treg, and Th17 cytokines were also monitored.
Results.
Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL).
Both PDGF and VEGF were significantly downregulated (P<0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later.
Conclusion.
The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group.
Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Poza-Guedes, Paloma& Barrios, Yvelise& Fuentes, Victoria& Franco, Andres& Sánchez-Machín, Inmaculada& Alonso, Elena…[et al.]. 2014. Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-466861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Poza-Guedes, Paloma…[et al.]. Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-466861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Poza-Guedes, Paloma& Barrios, Yvelise& Fuentes, Victoria& Franco, Andres& Sánchez-Machín, Inmaculada& Alonso, Elena…[et al.]. Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-466861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر