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Honey Supplementation in Spontaneously Hypertensive Rats Elicits Antihypertensive Effect via Amelioration of Renal Oxidative Stress
المؤلفون المشاركون
Gurtu, Sunil
Sulaiman, Siti Amrah
Erejuwa, Omotayo O.
Sirajudeen, Kuttulebbai N. S.
Ab Wahab, Mohd S.
Salleh, Salzihan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Oxidative stress is implicated in the pathogenesis and/or maintenance of elevated blood pressure in hypertension.
This study investigated the effect of honey on elevated systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR).
It also evaluated the effect of honey on the amelioration of oxidative stress in the kidney of SHR as a possible mechanism of its antihypertensive effect.
SHR and Wistar Kyoto (WKY) rats were randomly divided into 2 groups and administered distilled water or honey by oral gavage once daily for 12 weeks.
The control SHR had significantly higher SBP and renal malondialdehyde (MDA) levels than did control WKY.
The mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and glutathione S-transferase (GST) were significantly downregulated while total antioxidant status (TAS) and activities of GST and catalase (CAT) were higher in the kidney of control SHR.
Honey supplementation significantly reduced SBP and MDA levels in SHR.
Honey significantly reduced the activities of GST and CAT while it moderately but insignificantly upregulated the Nrf2 mRNA expression level in the kidney of SHR.
These results indicate that Nrf2 expression is impaired in the kidney of SHR.
Honey supplementation considerably reduces elevated SBP via amelioration of oxidative stress in the kidney of SHR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Erejuwa, Omotayo O.& Sulaiman, Siti Amrah& Ab Wahab, Mohd S.& Sirajudeen, Kuttulebbai N. S.& Salleh, Salzihan& Gurtu, Sunil. 2012. Honey Supplementation in Spontaneously Hypertensive Rats Elicits Antihypertensive Effect via Amelioration of Renal Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-466989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Erejuwa, Omotayo O.…[et al.]. Honey Supplementation in Spontaneously Hypertensive Rats Elicits Antihypertensive Effect via Amelioration of Renal Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-466989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Erejuwa, Omotayo O.& Sulaiman, Siti Amrah& Ab Wahab, Mohd S.& Sirajudeen, Kuttulebbai N. S.& Salleh, Salzihan& Gurtu, Sunil. Honey Supplementation in Spontaneously Hypertensive Rats Elicits Antihypertensive Effect via Amelioration of Renal Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-466989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-466989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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