Posttranslational Processing and Modification of Cathepsins and Cystatins
المؤلف
المصدر
Journal of Signal Transduction
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cathepsins are an essential protease family in all living cells.
The cathepsins play an essential roles such as protein catabolism and protein synthesis.
To targeting to various organella and to regulate their activity, the post translational-processing and modification play an important role Cathepsins are translated in polysome as the pre-pro-mature forms.
The pre-peptide is removed cotranslationally and then translocated to Golgi-apparatus and the pro-part is removed and the mature-part is glycosylated, and the mature-part is targeted into the lysosome mediated by mannose-6-phosphate signal and the mature-part is bound with their coenzymes.
The degradation of the mature-part is started by the limited proteolysis of the ordered nicked bonds to make hydrophobic peptides.
The peptides are incorporated into phagosome or proteasome after ubiquitinated and are degrade into amino-acids.
Cystatins are endogenous inhibitors of cathepsins.
Cystatin α which is only located in skin is phosphorylated at the near C-terminus by protein kinase-C, and the phosphorylate-cystatin α is incorporated into cornified envelope and conjugated with filaggrin-fiber by transglutaminase to form the linker-fiber of skin.
The cystatin α is modified by glutathione or make their dimmer, and they are inactive.
Those modifications are regulated by the redox-potential by the glutathione.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Katunuma, Nobuhiko. 2010. Posttranslational Processing and Modification of Cathepsins and Cystatins. Journal of Signal Transduction،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-467123
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Katunuma, Nobuhiko. Posttranslational Processing and Modification of Cathepsins and Cystatins. Journal of Signal Transduction No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-467123
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Katunuma, Nobuhiko. Posttranslational Processing and Modification of Cathepsins and Cystatins. Journal of Signal Transduction. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-467123
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467123
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر