Activation of the GLP-1 Receptor Signalling Pathway : A Relevant Strategy to Repair a Deficient Beta-Cell Mass

الملخص EN

Recent preclinical studies in rodent models of diabetes suggest that exogenous GLP-1R agonists and DPP-4 inhibitors have the ability to increase islet mass and preserve beta-cell function, by immediate reactivation of beta-cell glucose competence, as well as enhanced beta-cell proliferation and neogenesis and promotion of beta-cell survival.

These effects have tremendous implication in the treatment of T2D because they directly address one of the basic defects in T2D, that is, beta-cell failure.

In human diabetes, however, evidence that the GLP-1-based drugs alter the course of beta-cell function remains to be found.

Several questions surrounding the risks and benefits of GLP-1-based therapy for the diabetic beta-cell mass are discussed in this review and require further investigation.