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Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model
المؤلفون المشاركون
Teixeira, Frederico
Parada, Belmiro
Sereno, José
Teixeira de Lemos, Edite
Mota, Alfredo
Neto, Paula
Rocha-Pereira, Petronila
Cunha, Fernanda X.
Nunes, Sara
Rodrigues-Santos, Paulo
Garrido, Patrícia
Ruivo, José
Reis, Flávio
Pinto, Rui
Figueiredo, Arnaldo
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment.
The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), CEL: 10 mg/kg/day of the selective COX-2 inhibitor Celebrex, preventive CEL (CEL+BBN-P), and curative CEL (BBN+CEL-C) groups.
Although tumor growth was markedly inhibited by the preventive application of CEL, it was even aggravated by the curative treatment.
The incidence of gross bladder carcinoma was: control 0/8(0%), BBN 13/20(65%), CEL 0/8(0%), CEL+BBN-P 1/8(12.5%), and BBN+CEL-C 6/8(75%).
The number and volume of carcinomas were significantly lower in the CEL+BBN-P versus BBN, accompanied by an ample reduction in hyperplasia, dysplasia, and papillary tumors as well as COX-2 immunostaining.
In spite of the reduction of tumor volumes in the curative BBN+CEL-C group, tumor malignancy was augmented.
An anti-inflammatory and antioxidant profile was encountered only in the group under preventive treatment.
In conclusion, preventive, but not curative, celecoxib treatment promoted a striking inhibitory effect on bladder cancer development, reinforcing the potential role of chemopreventive strategies based on cyclooxygenase 2 inhibition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sereno, José& Parada, Belmiro& Reis, Flávio& Cunha, Fernanda X.& Teixeira de Lemos, Edite& Garrido, Patrícia…[et al.]. 2011. Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-467534
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sereno, José…[et al.]. Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model. Mediators of Inflammation No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-467534
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sereno, José& Parada, Belmiro& Reis, Flávio& Cunha, Fernanda X.& Teixeira de Lemos, Edite& Garrido, Patrícia…[et al.]. Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-467534
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467534
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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