![](/images/graphics-bg.png)
Adiponectin Ameliorates Endotoxin-Induced Acute Cardiac Injury
المؤلفون المشاركون
Watanabe, Yoshio
Murohara, Toyoaki
Ohashi, Koji
Kambara, Takahiro
Jie, Li
Ouchi, Noriyuki
Shibata, Rei
Komori, Kimihiro
Inoue, Yoko
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Obesity is a risk factor for cardiovascular disease.
Increasing evidence suggests that reduced levels of the adipocyte-derived plasma protein adiponectin are associated with an increased cardiovascular risk.
Here, we examined the effects of adiponectin on lipopolysaccharide- (LPS-) induced acute cardiac injury in vivo.
Methods and Results.
A single dose of LPS (10 mg/kg) was intraperitoneally injected into wild-type (WT) and adiponectin-knockout (APN-KO) mice.
Following LPS administration, APN-KO mice had exacerbation of left ventricular (LV) systolic dysfunction compared with WT mice.
Administration of LPS to WT and APN-KO mice led to an increased expression of inflammatory cytokines including TNF-α and IL-6 in the heart, but the magnitude of this induction was greater in APN-KO mice compared to WT mice.
Systemic delivery of an adenoviral vector expressing adiponectin (Ad-APN) improved LPS-induced LV dysfunction in APN-KO mice, and this effect was accompanied by the reduced expression of TNF-α and IL-6 in the heart.
Administration of etanercept, a soluble TNF receptor abolished the reduced LV contractile function in response to LPS in APN-KO mice.
Conclusion.
These results suggest that adiponectin protects against LPS-induced acute cardiac injury by suppressing cardiac inflammatory responses, and could represent a potential therapeutic target in sepsis-associated myocardial dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Watanabe, Yoshio& Shibata, Rei& Ouchi, Noriyuki& Kambara, Takahiro& Ohashi, Koji& Jie, Li…[et al.]. 2014. Adiponectin Ameliorates Endotoxin-Induced Acute Cardiac Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-467642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Watanabe, Yoshio…[et al.]. Adiponectin Ameliorates Endotoxin-Induced Acute Cardiac Injury. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-467642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Watanabe, Yoshio& Shibata, Rei& Ouchi, Noriyuki& Kambara, Takahiro& Ohashi, Koji& Jie, Li…[et al.]. Adiponectin Ameliorates Endotoxin-Induced Acute Cardiac Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-467642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)