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Neurofilament Phosphorylation during Development and Disease : Which Came First, the Phosphorylation or the Accumulation?
المؤلفون المشاركون
Garcia, Michael L.
Dale, Jeffrey M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Posttranslational modification of proteins is a ubiquitous cellular mechanism for regulating protein function.
Some of the most heavily modified neuronal proteins are cytoskeletal proteins of long myelinated axons referred to as neurofilaments (NFs).
NFs are type IV intermediate filaments (IFs) that can be composed of four subunits, neurofilament heavy (NF-H), neurofilament medium (NF-M), neurofilament light (NF-L), and α-internexin.
Within wild type axons, NFs are responsible for mediating radial growth, a process that determines axonal diameter.
NFs are phosphorylated on highly conserved lysine-serine-proline (KSP) repeats located along the C-termini of both NF-M and NF-H within myelinated axonal regions.
Phosphorylation is thought to regulate aspects of NF transport and function.
However, a key pathological hallmark of several neurodegenerative diseases is ectopic accumulation and phosphorylation of NFs.
The goal of this review is to provide an overview of the posttranslational modifications that occur in both normal and diseased axons.
We review evidence that challenges the role of KSP phosphorylation as essential for radial growth and suggests an alternative role for NF phosphorylation in myelinated axons.
Furthermore, we demonstrate that regulation of NF phosphorylation dynamics may be essential to avoiding NF accumulations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dale, Jeffrey M.& Garcia, Michael L.. 2012. Neurofilament Phosphorylation during Development and Disease : Which Came First, the Phosphorylation or the Accumulation?. Journal of Amino Acids،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dale, Jeffrey M.& Garcia, Michael L.. Neurofilament Phosphorylation during Development and Disease : Which Came First, the Phosphorylation or the Accumulation?. Journal of Amino Acids No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dale, Jeffrey M.& Garcia, Michael L.. Neurofilament Phosphorylation during Development and Disease : Which Came First, the Phosphorylation or the Accumulation?. Journal of Amino Acids. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467648
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