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Exenatide Pretreatment Improved Graft Function in Nonhuman Primate Islet Recipients Compared to Treatment after Transplant Only
المؤلفون المشاركون
Bergdall, Valerie K.
Buss, Jill L.
Rajab, Amer
Osei, Kwame
Essig, Elizabeth D.
Wang, Jie
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The GLP-1 receptor agonist, exenatide, has previously been shown to improve insulin secretion, protect beta cells from apoptosis, and promote beta cell regeneration.
We propose that pretreatment with exenatide will promote islet graft survival and improve graft function.
Pancreatectomized cynomolgus monkeys underwent islet allotransplantation and were treated with exenatide beginning on day 0 or day −2.
A third group of animals was treated with an immunosuppressive regimen while a fourth group remained untreated.
Fasting blood glucose (FBG) was used to evaluate graft function along with intravenous glucose tolerance tests (IVGTTs) performed at study endpoint (day 10 for untreated and posttransplant exenatide or day 90 for pretreatment exenatide and immunosuppression).
The average FBG for pre-treated animals day 5 following transplant was 52.7±14.8 mg/dl, compared to 154.3±105.5 mg/dl for animals treated only following transplant, 59.4 mg/dl ±12.1 for animals treated with immunosuppression, and 265.5±172.3 mg/dl for untreated animals.
IVGTTs performed at study endpoint showed normal glucose and insulin curves in the pre-treated exenatide and immunosuppression groups only, with beta cell function actually improving after transplant in the pre-treated group.
We conclude, therefore, that exenatide pre-treatment can successfully maintain islet graft survival in nonhuman primates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buss, Jill L.& Rajab, Amer& Essig, Elizabeth D.& Bergdall, Valerie K.& Wang, Jie& Osei, Kwame. 2012. Exenatide Pretreatment Improved Graft Function in Nonhuman Primate Islet Recipients Compared to Treatment after Transplant Only. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467680
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buss, Jill L.…[et al.]. Exenatide Pretreatment Improved Graft Function in Nonhuman Primate Islet Recipients Compared to Treatment after Transplant Only. Journal of Transplantation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467680
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buss, Jill L.& Rajab, Amer& Essig, Elizabeth D.& Bergdall, Valerie K.& Wang, Jie& Osei, Kwame. Exenatide Pretreatment Improved Graft Function in Nonhuman Primate Islet Recipients Compared to Treatment after Transplant Only. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467680
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467680
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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