PADI4 Haplotypes in Association with RA Mexican Patients, a New Prospect for Antigen Modulation
المؤلفون المشاركون
Moran-Moguel, Maria Cristina
Nava, Arnulfo
Sanchez-Corona, Jose
Gonzalez-Montoya, Norma Guadalupe
Davalos-Rodriguez, Ingrid Patricia
Rosales-Gomez, Roberto Carlos
Zavala-Cerna, María Guadalupe
Gonzalez-Lopez, Laura
Gamez-Nava, Jorge Ivan
Salazar-Paramo, Mario
Gutierrez-Rubio, Susan Andrea
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Peptidyl arginine deiminase IV (PAD 4) is the responsible enzyme for a posttranslational modification called citrullination, originating the antigenic determinant recognized by anti-cyclic citrullinated peptide antibodies (ACPA).
Four SNPs (single nucleotide polymorphisms) have been described in PADI4 gene to form a susceptibility haplotype for rheumatoid arthritis (RA); nevertheless, results in association studies appear contradictory in different populations.
The aim of the study was to analyze if the presence of three SNPs in PADI4 gene susceptibility haplotype (GTG) is associated with ACPA positivity in patients with RA.
This was a cross-sectional study that included 86 RA patients and 98 healthy controls.
Polymorphisms PADI4_89, PADI4_90, and PADI4_92 in the PADI4 gene were genotyped.
The susceptibility haplotype (GTG) was more frequent in RA patients; interestingly, we found a new haplotype associated with RA with a higher frequency (GTC).
There were no associations between polymorphisms and high scores in Spanish HAQ-DI and DAS-28, but we did find an association between RARBIS index and PADI4_89, PADI4_90 polymorphisms.
We could not confirm an association between susceptibility haplotype presence and ACPA positivity.
Further evidence about proteomic expression of this gene will determine its participation in antigenic generation and autoimmunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zavala-Cerna, María Guadalupe& Gonzalez-Montoya, Norma Guadalupe& Nava, Arnulfo& Gamez-Nava, Jorge Ivan& Moran-Moguel, Maria Cristina& Rosales-Gomez, Roberto Carlos…[et al.]. 2013. PADI4 Haplotypes in Association with RA Mexican Patients, a New Prospect for Antigen Modulation. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zavala-Cerna, María Guadalupe…[et al.]. PADI4 Haplotypes in Association with RA Mexican Patients, a New Prospect for Antigen Modulation. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-467782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zavala-Cerna, María Guadalupe& Gonzalez-Montoya, Norma Guadalupe& Nava, Arnulfo& Gamez-Nava, Jorge Ivan& Moran-Moguel, Maria Cristina& Rosales-Gomez, Roberto Carlos…[et al.]. PADI4 Haplotypes in Association with RA Mexican Patients, a New Prospect for Antigen Modulation. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر