The Role of Insulin and Insulin-Like Growth Factor-1FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia

المؤلفون المشاركون

Moll, Lorna
Schubert, Markus

المصدر

Current Gerontology and Geriatrics Research

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-13

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأمراض

الملخص EN

Epidemiological studies suggest that being obese in midlife is a risk factor for cognitive decline and dementia in later life.

Hyperinsulinemia is one of the most frequent endocrine features in overweight people which results in insulin desensitization.

Thus, chronically high insulin levels have been identified as risk factor for dementia.

Accordingly, chronically high insulin levels might be harmful for brain function.

Furthermore, insulin and IGF-1-induced signaling is reduced in the brains of patients suffering from Alzheimer’s disease (AD).

Interestingly, studies in rodents suggest that reduced insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) signaling decrease AD pathology, that is, β-amyloid toxicity.

Data obtained in C.

elegans indicate that the beneficial effect mediated via reduced IR/IGF-1R signaling might partially be induced via the forkhead-box O transcription factors (FoxO).

In the mammalian brain, there are FoxO1, FoxO3a, and FoxO6 expressed.

Surprisingly, high-fat diet specifically reduces the expression of FoxO3a and FoxO6 suggesting that IR/IGF-1 → FoxO-mediated transcription is involved in the pathogenesis of obesity-associated cognitive impairment.

Therefore, the function of FoxO1 and FoxO3a has been investigated in animal models of Alzheimer’s disease in detail.

The current paper focuses on the role of IR/IGF-1 signaling and IR/IGF-1 → FoxO-mediated transcription for the pathogenesis of obesity-associated dementia.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Moll, Lorna& Schubert, Markus. 2012. The Role of Insulin and Insulin-Like Growth Factor-1FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-467814

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Moll, Lorna& Schubert, Markus. The Role of Insulin and Insulin-Like Growth Factor-1FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-467814

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Moll, Lorna& Schubert, Markus. The Role of Insulin and Insulin-Like Growth Factor-1FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-467814

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-467814