Glucagon-Like Peptide-1 Receptor Imaging with [Lys40(Ahx-HYNIC-99mTcEDDA)NH2]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer : A Preliminary Report
المؤلفون المشاركون
Pach, D.
Tomaszuk, M.
Przybylik-Mazurek, E.
Janota, B.
Mikołajczak, R.
Jabrocka-Hybel, A.
Sowa-Staszczak, A.
Stefańska, A.
Hubalewska-Dydejczyk, A.
Trofimiuk-Müldner, M.
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Epidemiological studies on medullary thyroid cancer (MTC) have shown that neither a change in stage at diagnosis nor improvement in survival has occurred during the past 30 years.
In patients with detectable serum calcitonin and no clinically apparent disease, a careful search for local recurrence, and nodal or distant metastases, should be performed.
Conventional imaging modalities will not show any disease until basal serum calcitonin is at least 150 pg/mL.
The objective of the study was to present the first experience with labelled glucagon-like peptide-1 (GLP-1) analogue [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 in the visualisation of MTC in humans.
Material and Method.
Four patients aged 22–74 years (two with sporadic and two with MEN2 syndrome-related disseminated MTC) were enrolled in the study.
In all patients, GLP-1 receptor imaging was performed.
Results.
High-quality images were obtained in all patients.
All previously known MTC lesions have been confirmed in GLP-1 scintigraphy.
Moreover, one additional liver lesion was detected in sporadic MTC male patient.
Conclusions.
GLP-1 receptor imaging with [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 is able to detect MTC lesions.
GLP-1 scintigraphy can serve as a confirmatory test in MTC patients, in whom other imaging procedures are inconsistent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pach, D.& Sowa-Staszczak, A.& Jabrocka-Hybel, A.& Stefańska, A.& Tomaszuk, M.& Mikołajczak, R.…[et al.]. 2013. Glucagon-Like Peptide-1 Receptor Imaging with [Lys40(Ahx-HYNIC-99mTcEDDA)NH2]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer : A Preliminary Report. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-467845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pach, D.…[et al.]. Glucagon-Like Peptide-1 Receptor Imaging with [Lys40(Ahx-HYNIC-99mTcEDDA)NH2]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer : A Preliminary Report. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-467845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pach, D.& Sowa-Staszczak, A.& Jabrocka-Hybel, A.& Stefańska, A.& Tomaszuk, M.& Mikołajczak, R.…[et al.]. Glucagon-Like Peptide-1 Receptor Imaging with [Lys40(Ahx-HYNIC-99mTcEDDA)NH2]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer : A Preliminary Report. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-467845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر