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Crosstalk between Platelets and the Immune System : Old Systems with New Discoveries
المؤلفون المشاركون
Yougbare, Issaka
Li, Yan
Lang, Sean
Chen, Pingguo
Zhu, Guangheng
Ni, Heyu
Li, Conglei
Li, June
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-12
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Platelets are small anucleate cells circulating in the blood.
It has been recognized for more than 100 years that platelet adhesion and aggregation at the site of vascular injury are critical events in hemostasis and thrombosis; however, recent studies demonstrated that, in addition to these classic roles, platelets also have important functions in inflammation and the immune response.
Platelets contain many proinflammatory molecules and cytokines (e.g., P-selectin, CD40L, IL-1β, etc.), which support leukocyte trafficking, modulate immunoglobulin class switch, and germinal center formation.
Platelets express several functional Toll-like receptors (TLRs), such as TLR-2, TLR-4, and TLR-9, which may potentially link innate immunity with thrombosis.
Interestingly, platelets also contain multiple anti-inflammatory molecules and cytokines (e.g., transforming growth factor-β and thrombospondin-1).
Emerging evidence also suggests that platelets are involved in lymphatic vessel development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2.
Besides the active contributions of platelets to the immune system, platelets are passively targeted in several immune-mediated diseases, such as autoimmune thrombocytopenia, infection-associated thrombocytopenia, and fetal and neonatal alloimmune thrombocytopenia.
These data suggest that platelets are important immune cells and may contribute to innate and adaptive immunity under both physiological and pathological conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Conglei& Li, June& Li, Yan& Lang, Sean& Yougbare, Issaka& Zhu, Guangheng…[et al.]. 2012. Crosstalk between Platelets and the Immune System : Old Systems with New Discoveries. Advances in Hematology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-467864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Conglei…[et al.]. Crosstalk between Platelets and the Immune System : Old Systems with New Discoveries. Advances in Hematology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-467864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Conglei& Li, June& Li, Yan& Lang, Sean& Yougbare, Issaka& Zhu, Guangheng…[et al.]. Crosstalk between Platelets and the Immune System : Old Systems with New Discoveries. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-467864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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