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Genetic Predisposition to Familial Nonmedullary Thyroid Cancer : An Update of Molecular Findings and State-of-the-Art Studies
المؤلفون المشاركون
Romeo, Giovanni
Tallini, Giovanni
Bonora, Elena
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Familial thyroid cancer has become a well-recognized entity in patients with thyroid cancer originating from follicular cells, that is, nonmedullary thyroid carcinoma.
The diagnosis of familial thyroid cancer provides an opportunity for early detection and possible prevention in family members.
Understanding the syndromes associated with familial thyroid cancer allows clinicians to evaluate and treat patients for coexisting pathologic conditions.
About five percents of patients with well-differentiated thyroid carcinoma have a familial disease.
Patients with familial non-medullalry thyroid cancer have more aggressive tumors with increased rates of extrathyroid extension, lymph node metastases, and frequently show the phenomenon of “anticipation” (earlier age at disease onset and increased severity in successive generations).
So far, four predisposition loci have been identified in relatively rare extended pedigrees, and association studies have identified multiple predisposing variants for differentiated thyroid cancer.
This suggests that there is a high degree of genetic heterogeneity and that the development of this type of tumor is a multifactorial and complex process in which predisposing genetic variants interact with a number of incompletely understood environmental risk factors.
Thus, the search for the causative variants is still open and will surely benefit from the new technological approaches that have been developed in recent years.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bonora, Elena& Tallini, Giovanni& Romeo, Giovanni. 2010. Genetic Predisposition to Familial Nonmedullary Thyroid Cancer : An Update of Molecular Findings and State-of-the-Art Studies. Journal of Oncology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467912
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bonora, Elena…[et al.]. Genetic Predisposition to Familial Nonmedullary Thyroid Cancer : An Update of Molecular Findings and State-of-the-Art Studies. Journal of Oncology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-467912
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bonora, Elena& Tallini, Giovanni& Romeo, Giovanni. Genetic Predisposition to Familial Nonmedullary Thyroid Cancer : An Update of Molecular Findings and State-of-the-Art Studies. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-467912
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-467912
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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