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Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population : A Cross-Sectional Study
المؤلفون المشاركون
Gupta, Shachin K.
Vyas, Prerna
Bose, K. Subhash Chandra
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
In view of the noteworthy role of adipocytokines in the onset of insulin resistance and diabetes in gene-knockout-rat-model-cell-line studies we aimed to study the influence of genetic predisposition for diabetes on adipocytokine levels and their role in building insulin-resistance-like environment well before the onset of diabetes; thus a hypothesis can be drawn on their role in developing diabetes in high risk population.
Methods.
Ages between 18 and 22 years were selected and divided into three groups.
Group I (n=81): control group with no family history of diabetes.
Group II (n=157): with one of their parents with history of type 2 diabetes.
Group III (n=47): with both parents having history of type 2 diabetes.
In all the groups we estimated fasting plasma glucose, insulin and adipocytokines like adiponectin, leptin, TNF-α, and IL-6.
Results.
Of all adipocytokines we observed significantly lower levels of adiponectin (8.7±1 μg/mL in group III and 9.5±1.3 μg/mL group II) when compared to control (11.0±1.2 μg/mL; P<0.01) and it has strong correlation with family history of diabetes with Pearson’s coefficient of −0.502.
Linear regression analysis showed significant negative association with HOMA-IR (P<0.01) and logistic regression analysis showed highest association with parental diabetes (P<0.01; OR .260, 95% CI .260–.468).
Conclusion.
Genetic predisposition for diabetes may influence adiponectin gene expression leading to decrease in its plasma concentration, which might play a key role in developing diabetes in near future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bose, K. Subhash Chandra& Gupta, Shachin K.& Vyas, Prerna. 2012. Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population : A Cross-Sectional Study. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bose, K. Subhash Chandra…[et al.]. Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population : A Cross-Sectional Study. Experimental Diabetes Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-468039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bose, K. Subhash Chandra& Gupta, Shachin K.& Vyas, Prerna. Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population : A Cross-Sectional Study. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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