Comparison of OxidantAntioxidant, Detoxification Systems in Various Tissue Homogenates and Mitochondria of Rats with Diabetes Induced by Streptozocin
المؤلفون المشاركون
Çelık, Veysel Kenan
Şahın, Zeynep Deniz
Bakir, Sevtap
Sari, İsmail
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Oxidative stress is considered to be the main factor in the development of diabetic complications and tissue injury.
our objective was to investigate and compare the oxidant/antioxidant conditions and detoxification mechanisms of the liver, lung, kidney, cardiac tissues, and mitochondria of rats with diabetes induced by streptozocin (STZ).
Methods.
Rats with diabetes induced by streptozocin were anesthetized by administering 90 mg/kg ketamine hydrochloride and 3 mg/kg xylazine hydrochloride.
Thoracic cavities were incised open; liver, lung, kidney, and cardiac tissues were removed and stored at −70°C.
All samples were homogenized and mitochondrial fractions were separated.
Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Paraoxonase (PON), Arylesterase, Catalase (Cat), Malondialdehyde (MDA), and Glutathion-S-transferase were measured in each fraction.
Results.
MDA and TOS levels were significantly increased in liver tissues, and T OS and OSI were increased in the mitochondrial fractions of diabetic rats.
These increases were not statistically significant compared to the control group.
No significant differences were determined in the antioxidant and GST activities.
Conclusion.
According to our results, oxidative stress has not developed in rats with diabetes induced by streptozocin.
The detoxification system was induced; however, this induction did not differ significantly from the controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Çelık, Veysel Kenan& Şahın, Zeynep Deniz& Sari, İsmail& Bakir, Sevtap. 2012. Comparison of OxidantAntioxidant, Detoxification Systems in Various Tissue Homogenates and Mitochondria of Rats with Diabetes Induced by Streptozocin. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-468067
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Çelık, Veysel Kenan…[et al.]. Comparison of OxidantAntioxidant, Detoxification Systems in Various Tissue Homogenates and Mitochondria of Rats with Diabetes Induced by Streptozocin. Experimental Diabetes Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-468067
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Çelık, Veysel Kenan& Şahın, Zeynep Deniz& Sari, İsmail& Bakir, Sevtap. Comparison of OxidantAntioxidant, Detoxification Systems in Various Tissue Homogenates and Mitochondria of Rats with Diabetes Induced by Streptozocin. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-468067
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468067
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر