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Novel Pharmacological Approaches for Inflammatory Bowel Disease : Targeting Key Intracellular Pathways and the IL-23IL-17 Axis
المؤلف
المصدر
International Journal of Inflammation
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This review identifies possible pharmacological targets for inflammatory bowel disease (IBD) within the IL-23/IL-17 axis.
Specifically, there are several targets within the IL-23/IL-17 pathways for potential pharmacological intervention with antibodies or small molecule inhibitors.
These targets include TL1A (tumor necrosis factor-like molecule), DR3 (death receptor 3), IL-23, IL-17 and the receptors for IL-23 and IL-17.
As related to IBD, there are also other novel pharmacological targets.
These targets include inhibiting specific immunoproteasome subunits, blocking a key enzyme in sphingolipid metabolism (sphingosine kinase), and modulating NF-κB/STAT3 interactions.
Several good approaches exist for pharmacological inhibition of key components in the IL-23 and IL-17 pathways.
These approaches include specific monoclonal antibodies to TL1A, IL-17 receptor, Fc fusion proteins, specific antibodies to IL-17F, and small molecule inhibitors of IL-17 like Vidofludimus.
Also, other potential approaches for targeted drug development in IBD include specific chemical inhibitors of SK, specific small molecule inhibitors directed against catalytic subunits of the immunoproteasome, and dual inhibitors of the STAT3 and NF-κB signal transduction systems.
In the future, well-designed preclinical studies are still needed to determine which of these pharmacological approaches will provide drugs with the best efficacy and safety profiles for entrance into clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fitzpatrick, Leo R.. 2012. Novel Pharmacological Approaches for Inflammatory Bowel Disease : Targeting Key Intracellular Pathways and the IL-23IL-17 Axis. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-468230
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fitzpatrick, Leo R.. Novel Pharmacological Approaches for Inflammatory Bowel Disease : Targeting Key Intracellular Pathways and the IL-23IL-17 Axis. International Journal of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-468230
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fitzpatrick, Leo R.. Novel Pharmacological Approaches for Inflammatory Bowel Disease : Targeting Key Intracellular Pathways and the IL-23IL-17 Axis. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-468230
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468230
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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