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Randomized Controlled Trial of Clozapine and CBT for First-Episode Psychosis with Enduring Positive Symptoms : A Pilot Study
المؤلفون المشاركون
Burnett, P.
Yuen, H. P.
Maud, D.
McGorry, Patrick D.
Edwards, J.
Wong, L.
Cocks, J.
Wade, D.
Herrman-Doig, T.
Harrigan, S. M.
Murphy, B.
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Here we report the results of a pilot study investigating the relative and combined effects of a 12 week course of clozapine and CBT in first-episode psychosis patients with prominent ongoing positive symptoms following their initial treatment.
Patients from our early psychosis service who met the inclusion criteria (n=48) were randomized to one of four treatment groups: clozapine, clozapine plus CBT, thioridazine, or thioridazine plus CBT.
The degree of psychopathology and functionality of all participants was measured at baseline then again at 6, 12 and 24 weeks, and the treatment outcomes for each group determined by statistical analysis.
A substantial proportion (52%) of those treated with clozapine achieved symptomatic remission, as compared to 35% of those who were treated with thioridazine.
Overall, those who received clozapine responded more rapidly to treatment than those receiving the alternative treatments.
Interestingly, during the early treatment phase CBT appeared to reduce the intensity of both positive and negative symptoms and thus the time taken to respond to treatment, as well having as a stabilizing effect over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Edwards, J.& Cocks, J.& Burnett, P.& Maud, D.& Wong, L.& Yuen, H. P.…[et al.]. 2011. Randomized Controlled Trial of Clozapine and CBT for First-Episode Psychosis with Enduring Positive Symptoms : A Pilot Study. Schizophrenia Research and Treatment،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468721
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Edwards, J.…[et al.]. Randomized Controlled Trial of Clozapine and CBT for First-Episode Psychosis with Enduring Positive Symptoms : A Pilot Study. Schizophrenia Research and Treatment No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468721
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Edwards, J.& Cocks, J.& Burnett, P.& Maud, D.& Wong, L.& Yuen, H. P.…[et al.]. Randomized Controlled Trial of Clozapine and CBT for First-Episode Psychosis with Enduring Positive Symptoms : A Pilot Study. Schizophrenia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468721
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468721
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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