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The Herbal Drug Melampyrum pratense L. (Koch) : Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation
المؤلفون المشاركون
Wawrosch, C.
Reznicek, G.
Atanasov, Atanas G.
Heiss, E. H.
Urban, E.
Kopp, B.
Saukel, J.
Dirsch, V. M.
Bochkov, V.
Vogl, S.
Fakhrudin, N.
Zehl, M.
Picker, P.
Binder, M.
Bulusu, M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Melampyrum pratense L.
(Koch) is used in traditional Austrian medicine for the treatment of different inflammation-related conditions.
In this work, we show that the extracts of M.
pratense stimulated peroxisome proliferator-activated receptors- (PPARs-)α and -γ that are well recognized for their anti-inflammatory activities.
Furthermore, the extract inhibited the activation of the proinflammatory transcription factor NF-κB and induction of its target genes interleukin-8 (IL-8) and E-selectin in vitro.
Bioassay-guided fractionation identified several active flavonoids and iridoids including melampyroside and mussaenoside and the phenolic compound lunularin that were identified in this species for the first time.
The flavonoids apigenin and luteolin were distinguished as the main components accountable for the anti-inflammatory properties.
Apigenin and luteolin effectively inhibited tumor necrosis factor α (TNF-α)-induced NF-κB-mediated transactivation of a luciferase reporter gene.
Furthermore, the two compounds dose-dependently reduced IL-8 and E-selectin protein expression after stimulation with lipopolysaccharide (LPS) or TNF-α in endothelial cells (ECs).
The iridoids melampyroside and mussaenoside prevented the elevation of E-selectin in LPS-stimulated ECs.
Lunularin was found to reduce the protein levels of the proinflammatory mediators E-selectin and IL-8 in ECs in response to LPS.
These data validate the ethnomedical use of M.
pratense for the treatment of inflammatory conditions and point to the constituents accountable for its anti-inflammatory activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vogl, S.& Atanasov, Atanas G.& Binder, M.& Bulusu, M.& Zehl, M.& Fakhrudin, N.…[et al.]. 2013. The Herbal Drug Melampyrum pratense L. (Koch) : Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vogl, S.…[et al.]. The Herbal Drug Melampyrum pratense L. (Koch) : Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-468753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vogl, S.& Atanasov, Atanas G.& Binder, M.& Bulusu, M.& Zehl, M.& Fakhrudin, N.…[et al.]. The Herbal Drug Melampyrum pratense L. (Koch) : Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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